Use of Radiomics in Low Dose Chest CT: A Proposal for a Phantom Multi-Centric Study

Maria Irene Tenerani, Maria Irene Tenerani, Silvia Arezzini, Antonino Formuso, Francesca Lizzi, Enrico Mazzoni, Stefania Pallotta, Stefania Pallotta, Stefania Pallotta, Alessandra Retico, Camilla Scapicchio, Cinzia Talamonti, Cinzia Talamonti, Cinzia Talamonti, Maria Evelina Fantacci, Maria Evelina Fantacci

2025

Abstract

Radiomics is a quantitative biomedical image analysis tool involving the mathematical extraction of image features that can be used, particularly in oncology, to build predictive models based on artificial intelligence for diagnosis and treatment outcome prediction. In Lung cancer screening via Low-Dose Computed Tomography (LDCT), radiomics-based models could increase lung nodules detectability simplifying the implementation of large-scale screening. However, their transposition into clinical practice is slowed by the instability that radiomic feature values show in changes in CT image acquisition and reconstruction parameters. To build more robust models, it is essential to conduct multi-centric radiomic studies leveraging the use of various types of phantoms to overcome the challenges associated with patient data complexity. However, many difficulties may arise related to both the image acquisition and reconstruction process and the extraction and analysis of radiomic features. In this paper, from the results of a pilot study conducted with two phantoms, guidelines for a multi-centric radiomic study on phantoms LDCTs are proposed, focusing on crucial aspects such as phantom positioning, image acquisition and reconstruction protocol, and radiomic feature extraction pipeline. Finally, a XNAT-based platform for data sharing and management, image quality control implementation and radiomic feature extraction automation is proposed.

Paper Citation

in Harvard Style

Tenerani M., Arezzini S., Formuso A., Lizzi F., Mazzoni E., Pallotta S., Retico A., Scapicchio C., Talamonti C. and Fantacci M. (2025). Use of Radiomics in Low Dose Chest CT: A Proposal for a Phantom Multi-Centric Study. In Proceedings of the 18th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 1: BIOIMAGING; ISBN 978-989-758-731-3, SciTePress, pages 403-412. DOI: 10.5220/0013377300003911

in Bibtex Style

@conference{bioimaging25,
author={Maria Tenerani and Silvia Arezzini and Antonino Formuso and Francesca Lizzi and Enrico Mazzoni and Stefania Pallotta and Alessandra Retico and Camilla Scapicchio and Cinzia Talamonti and Maria Fantacci},
title={Use of Radiomics in Low Dose Chest CT: A Proposal for a Phantom Multi-Centric Study},
booktitle={Proceedings of the 18th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 1: BIOIMAGING},
year={2025},
pages={403-412},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0013377300003911},
isbn={978-989-758-731-3},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 18th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 1: BIOIMAGING
TI - Use of Radiomics in Low Dose Chest CT: A Proposal for a Phantom Multi-Centric Study
SN - 978-989-758-731-3
AU - Tenerani M.
AU - Arezzini S.
AU - Formuso A.
AU - Lizzi F.
AU - Mazzoni E.
AU - Pallotta S.
AU - Retico A.
AU - Scapicchio C.
AU - Talamonti C.
AU - Fantacci M.
PY - 2025
SP - 403
EP - 412
DO - 10.5220/0013377300003911
PB - SciTePress